Logically, this discovery sparked an interest in scientists to explore if CBD could convert to THC in the stomach. Especially considering that this conversion could never happen using other cannabis consumption methods, such as inhalation or topicals. So, what have they found?
Most cannabis consumers know that the cannabinoids CBD and THC are pretty similar. The two main components found in weed however, vary significantly. CBD is non-psychoactive, as it has only a weak ability to activate the CB1-receptor in the endocannabinoid system. On the other hand, the substance is classified as a negative allosteric modulator of CB1-receptors from the ECS. Meaning it affects the receptors (found throughout the human body) so that cannabinoids like THC – or your body’s own THC, anandamide – are not well absorbed.
Acid Changes CBD
Another study though, used gastric juice with a slightly different pH compared to that of stomach acid. Here, the conversion rate was only 2,9%. Considering the different compositions produce various results, means we should be careful interpreting this data.
Well, one study used artificial gastric fluid. Obviously this was adjusted to pH 1, to mimic the acidity of actual gastric fluid. The CBD in the study was dissolved in methanol, resulting in a 85% isomerization of the present CBD; into a mixture of D9- and D8-THC.
CBD solutions are known to be pretty unstable. They have to be stored in a dark place, below 8 Degrees Celsius. Under different, more acidic conditions, CBD could possibly turn into THC and other cannabinoids. A process known as isomerization – with at least two possible consequences:
In recent years, interest in medical marijuana for digestive issues has increased.
Some other common stomach ulcer symptoms include:
Nowadays, people use cannabis to address a whole range of medical conditions, including digestive issues like stomach ulcers.
Cannabis for Stomach Ulcer Symptom Relief
There is some evidence that cannabis could help stomach ulcers, although it may be more useful for prevention than cure. It appears to protect the digestive system through its influence on the body’s endocannabinoid system.
When these bacteria colonize the stomach, they cause inflammation (gastritis), which can eventually lead to ulceration. H. pylori are responsible for as many as 70–90% of gastric ulcers.
There are some obvious benefits to using marijuana for digestive problems. For example, we know that cannabinoids like THC and CBD can relieve nausea and pain symptoms. But can cannabis heal stomach ulcers, or is this just wishful thinking?
Clinicians usually treat stomach ulcers with medications called proton pump inhibitors (PPIs). They include drugs like omeprazole and lansoprazole.