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Is it Safe to Use CBD and Zoloft (sertraline) at the same time?

In our latest question and answer, the medical cannabis pharmacist discusses if it is ok to use CBD oil while taking sertraline.

Answered by: Dr. Geoffrey Brown, PharmD

Khia Asked

I take Zoloft for my depression and would like to start supplementing CBD to reduce inflammation and help with anxiety. Is it safe to use with Zoloft?

Summary

There is limited data available on CBD’s potential to cause interactions with sertraline (Zoloft).
CBD may inhibit metabolic enzymes involved in the metabolism of sertraline but, the chances of CBD causing clinically significant interactions with sertraline are rather low.
Be sure to let your psychiatrist or doctor that manages your sertraline therapy know that you’re using CBD.

Answer

Hi Khia, and thank you for your question. While I couldn’t find any studies investigating this interaction in particular, I was able to find some information regarding the metabolism of both of drugs which can help us answer questions about the likelihood of an interaction.

In short, CBD may inhibit some of the enzymes that’re involved in the metabolism of sertraline (Zoloft). Therefore, theoretically, there is a possibility the two could interact. However, the likelihood that this interaction would be clinically significant or something you need to be concerned with is rather low.

Sertraline (Brand name Zoloft) is a selective serotonin reuptake inhibitor or SSRI and is the most commonly prescribed antidepressant medication in the United States. Sertraline is metabolized by a number of CYP enzymes present in the liver including CYP2B6 and to a lesser extent CYP2C19, CYP2C9, CYP3A4, and CYP2D6 . According to the manufacturer’s package insert for sertraline, that’s reviewed by the FDA, dose reductions may be warranted in patients treated with sertraline that are taking other drugs metabolized by these enzymes.

Cannabidiol (CBD) is the primary non-euphoric cannabinoid in cannabis/hemp and is now a common ingredient in many health and consumer products. One of the most commonly claimed indications for CBD is anxiety. Preliminary evidence suggests CBD shows promise as a potential treatment for anxiety, but the doses researched vary greatly between studies.

CBD is also metabolized by CYP enzymes in the liver, so using CBD may alter the way these enzymes function in regard to their ability to metabolize other drugs such as sertraline.

According to the package insert for the FDA approved CBD oral solution, CBD is metabolized by CYP3A4 and CYP2C19, and has the potential to inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19. Therefore, because CBD can inhibit some of the same enzymes that’re responsible for the metabolism of sertraline, there’s a possibility that CBD could reduce the metabolism of sertraline leading to increased concentrations of the drug in the body increasing the risk of adverse effects due to sertraline.

While there’s certainly a theoretical basis for this interaction, I would not be too concerned about this from a safety standpoint for two reasons. For one, the blood concentrations of CBD needed to inhibit these enzymes aren’t likely to be achieved by CBD taken at usual doses. The second reason is because multiple CYP enzymes are responsible for the metabolism of sertraline it would be difficult for CBD alone to cause a serious interaction by interfering with just one or even a couple of those enzymes. That being said, i t’s still a good idea to let your doctor of psychiatrist that manages your sertraline therapy know that you’re using CBD. That way they can monitor for any changes or adverse effects from changes in sertraline metabolism.

To summarize, there’s a possibility an interaction between CBD and sertraline could occur, but unless you’re consistently using high doses of CBD (upwards of 100 mg multiple times per day) I wouldn’t worry too much about it. I hope this helps answer your question.

Thanks again Khia. Please don’t hesitate to reach out again in the future with any cannabis questions you have.

References

Zoloft [package insert]. New York, NY: Pfizer, Inc. 2016.

Epidiolex [ package insert ]. Carlsbad, CA: Greenwich Biosciences, Inc. 2020.

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He cleaned the Guanyinyan Station here. After the battlefield, they also seized rx green patches some supernatural items, weapons and equipment.

At first glance, these two are not Qin Daoren and Qin can you use cbd oil with zoloft Li.

Don t Qin Shaoyou said hurriedly, Sandy Beach Hotel can you use cbd oil with zoloft It s a froggy cbd gummies pity to destroy it, give it to me.

He didn t know much about auxiliary spells, not to mention the spells Ye Zhiqiu used, Good cbd gummies get you high obviously after joining the Demon Suppression Division, he systematically sorted out and studied can you use cbd oil with zoloft the various situations faced by the investigation.

After a few words, he said goodbye and left.

In addition, the detailed process of this mission, as well as Li Ananda s death, as well as the simultaneous arrests in Luocheng, can you use cbd oil with zoloft must be reported to Zuo Qianhu in can you use cbd oil with zoloft detail.

Could it be the can you use cbd oil with zoloft ghosts of the Black Lotus Sect demons Shan Daonian can you use cbd oil with zoloft frowned when he heard the words Isn t it possible The Black Lotus cbd gummies get you high What Is A Good Cbd Oil Sect demons in Mianyuan County have been Sandy Beach Hotel can you use cbd oil with zoloft swept away in the past two months, where can they still be Have the strength to do such a thing Now they don t can you use cbd oil with zoloft have the strength to toss the drought in Mianyuan County, but what about before make cannabis gummies Before According to the news from Xiucai, can you use cbd oil with zoloft this drought started a few months ago.

Zhu Xiucai was stunned for a moment The how do you know what dosage of cbd oil is best ear of the partition wall and the eye of the partition wall What the hell can you use cbd oil with zoloft is that Without waiting for him to ask, Qin Shaoyou explained it with his actions.

As if to say Got it, Cbd Oil For Tremors can you use cbd oil with zoloft get out of here. Qin Shaoyou has a black line, and wants to ask the ancestor statue, are you polite 7017k Qin Shaoyou thought it was all about this time, and the family must have already slept and rested.

It is a pity that the supernatural item has been damaged, otherwise it will be used to deal with the can you use cbd oil with zoloft corpse raising demon and the corpse king.

There is can you use cbd oil with zoloft a play. Qin Shaoyou was secretly can you use cbd oil with zoloft happy.

But in the end he resisted cbd gummies get you high What Is A Good Cbd Oil the urge. Paranormal items also have various side effects, some of can you use cbd oil with zoloft which are powerful and even threaten the user s life.

Although they were deeply regretful, they all urged anxiously Qin can you use cbd oil with zoloft Zongqi, get Cbd Oil Recommended Dosage can you use cbd oil with zoloft out , can you use cbd oil with zoloft don t fight Withdraw Quickly withdraw At the same time, they also launched a new round of attacks in the direction can you use cbd oil with zoloft of the stone tortoise incense burner, wanting to continue to consume the power of the feng shui Cbd Oil For Tremors can you use cbd oil with zoloft array to cover Qin Shaoyou s withdrawal.

It s a pity can you use cbd oil with zoloft that it met Qin Shaoyou. Qin Shaoyou s improving eyesight talent is the most capable of discovering these subtle changes.

Zuo Qianhu, Liao Tixue and others were also does cbd oil help heal injuries looking at the ghost tree full of grimaces.

He tried the Lingguan seal on him, and confirmed the handprints and mantras he learned in the dream.

The Demon Slayer Hammer and Demon Slayer Sword can you use cbd oil with zoloft in his hand kept waving and falling, killing several evil spirits in a row.

So he was relieved, and swiftly rolled into the kitchen.

However, before Shuanggui Cbd Oil For Tremors can you use cbd oil with zoloft Village arrived, it was in this dark night that the night watchmen discovered some strange situations that were different from other places Sir, something is not quite right tonight Zhu Xiucai drove to Qin Shaoyou side, said in a low voice.

After the incident, Cui Youkui performed the earth escape technique, and Qin Shaoyou affixed a earth escape talisman on his body.

An Zizhan s young mind was deeply shocked by this My grandfather dares to drink swill No He not only dares to drink, but also likes to drink it.

Boom Qin Shaoyou smashed the black light with a hammer, and the turmoil was endless.

A group of people just lie on the Chase bunk, cursing a certain official, they are full and have nothing to do In the library, Qin Shaoyou can you use cbd oil with zoloft sneezed. He didn t think too much.

Lai Cha was frightened and threw himself on the ground, screaming again and again Don t dare to lie, don t dare is cbd oil good for your hair to lie, I saw with my own eyes that it was Shen Bin who chopped off Xiang Piao Piao s head Ah, don t kill me, cbd gummies get you high What Is A Good Cbd Oil I really don t have one.

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Then he shook his head and said, This gift giver is so ignorant, don t choose this time to give gifts.

Rao is a man of extensive knowledge and knowledge.

Qin Shaoyou not only was not frightened by these grimace, but he couldn t help swallowing.

If it goes on can you use cbd oil with zoloft like this, I m afraid it won t be long before I fall out of the realm of an eighth rank martial artist.

At this moment, he can you use cbd oil with zoloft widened his eyes, grinned and closed his teeth.

But the can you use cbd oil with zoloft cowhide you blew has to be finished with tears.

Of course, An Mutong did not come alone, he also can you use cbd oil with zoloft brought how do i properly dispense cbd oil a group of yamen and officials.

Cui Youkui, who was at the same table, glanced at him.

Qin Shaoyou praised Well done , and then said When the reinforcement operation is over, I will issue you an official arrest document.

An Mutong went home to inform his wife of the good news, Good cbd gummies get you high while Qin Shaoyou and Xue Qingshan returned to the station to rest with one of his men.

In the sound what happens if you eat expired cbd gummies of the incantation, the cassock changed rapidly, revealing its original appearance a robe made of countless pieces stitched together.

Accident I believe you are strange, since you burrowed into the ground to hide as soon as you picked up a pen, you knew that this was the norm rather than an accident.

After Su Tingyu was amazed, he said, In this way, President Qin and our Taoist sect are quite related.

Just when Qin Shaoyou frowned, Cui can you use cbd oil with zoloft Youkui came up.

He was Cbd Oil For Tremors can you use cbd oil with zoloft already old, and the rain caused him to become seriously ill.

Cui Youkui knew that Qin Shaoyou was asking him to see other torture instruments in the government office, and whether there was a possibility can you use cbd oil with zoloft of becoming entourage season online a demon.

Zhu Xiucai Good cbd gummies get you high nodded in agreement There is indeed such a can you use cbd oil with zoloft best cbd gummies no corn syrup possibility.

Qin Shaoyou had heard of this Dongchuan Hou, and he had been leading troops here in Yizhou, not only to suppress the rebels who rebelled, but also responsible for deterring several major chieftains in Yizhou, and guarding against the barbarians in Qingtang.

After all, he had a lot of talismans on him.

It was a bit rude to actually not cbd vape hemp oil offer it spiritual food in return.

In this battle, Qin Shaoyou opened four new dishes in total.

But now that he has a wealth of experience, he is not nervous at all, turning his head to look in the direction of the lobby.

Liao Shaozhuo took the medicine and took a few breaths at most, and then Cbd Oil For Tremors can you use cbd oil with zoloft they felt that the river was upside down in the stomach, and it seemed that something was can you use cbd oil with zoloft frantically tossing in it, and the flesh on their stomachs could even be seen moving with can you use cbd oil with zoloft the naked can you use cbd oil with zoloft eye.

Because he Cbd Oil Recommended Dosage can you use cbd oil with zoloft knew that the results of the divination were not completely accurate, and there might still be accidents.

What s more, Qin can you use cbd oil with zoloft Shaoyou can see clearly through the talent of Bright Eyes , that corpse bats are can you use cbd oil with zoloft Sandy Beach Hotel can you use cbd oil with zoloft not only poisonous on their teeth and claws, but also corpse poison is constantly coming out from the rotten can you use cbd oil with zoloft and can you use cbd oil with zoloft festering wounds can you use cbd oil with zoloft on their bodies.

Qin Shaoyou knew without using Debate and Listening that Monk Ma must be preaching scriptures to the dancer at this moment, trying to persuade her to follow her path and get the dancer Sandy Beach Hotel can you use cbd oil with zoloft out of the sea of what does cbd oil do for athletes misery.

But soon, he found Sandy Beach Hotel can you use cbd oil with zoloft the can you use cbd oil with zoloft situation on Xue Qingshan s face, and sneered How Cbd Oil Recommended Dosage can you use cbd oil with zoloft dare you Good cbd gummies get you high talk about me The rouge on your face hasn t been wiped clean.

Although where to order cbd oil with thc they have not been Cbd Oil Recommended Dosage can you use cbd oil with zoloft away from home for a long time, the experience is extraordinary.

Through the moonlight, Qin Shaoyou could see their clothes clearly.

And now, although Zhang Liu is a living dead, he still needs to is cbd cream safe during pregnancy eat in can you use cbd oil with zoloft water, so Zhang He still follows his usual habit and often brings Zhang Liu over to eat.

When they know the mysterious tree called Fusang Ghost Tree, they may be able to infer many can you use cbd oil with zoloft Liv Labs Cbd Oil Reviews clues, so that Qin Shaoyou s curious and confused questions can be answered.

You might cbd oil in utah as well say, How can you use cbd oil with zoloft dare Cuimen Cbd Oil Recommended Dosage can you use cbd oil with zoloft make a talisman , or No Fu Lu dares to do something to Sandy Beach Hotel can you use cbd oil with zoloft me, can you use cbd oil with zoloft let me blow it up, and so on, it s even more pretentious.

Sure enough, walking the stomach is also a good way to quickly increase your goodwill After Qin Shaoyou agreed with Su Jianqing and Su Tingyu for a high five, he asked about the supernatural material of the meaning of tack Self inflicted Freedom card.

This Mianyuan County is actually suffering from a drought To be precise, it is not only Mianyuan County that suffers from the drought.

Anyway, in Xiang Piao Piao s pupils, he didn t can you use cbd oil with zoloft see any pictures before death, but combined with the remaining expressions Sandy Beach Hotel can you use cbd oil with zoloft on his eyes and face, he saw her panic.

Because Xue Qingshan wanted him can you use cbd oil with zoloft to go the Cbd Oil For Tremors can you use cbd oil with zoloft way of a civil servant, and he didn t want him to follow in his own footsteps and spend his days licking can you use cbd oil with zoloft blood with a knife Cbd Oil For Tremors can you use cbd oil with zoloft in the Demon Suppression Division.

The two sisters conservatively estimated that it can you use cbd oil with zoloft Liv Labs Cbd Oil Reviews would take a month or two.

Xue Qingshan was used to Qin Shaoyou can you use cbd oil with zoloft s cautious approach and didn t say anything.

You are really blind. With Good cbd gummies get you high me here, why do you need to ask others Isn t it just a few five element escape talismans I ll draw it for you Cui Youkui patted his chest and took it all in.

Qin Shaoyou was about to ask why he was Cbd Oil Recommended Dosage can you use cbd oil with zoloft dissatisfied with the statue of the ancestor of Jiutian Dangmo, when he saw the wisps of can you use cbd oil with zoloft Cbd Oil For Anxiety And Depe blue can you use cbd oil with zoloft smoke in front of the statue, surging together and turning into a picture.

Take care of me. Are you just giving can you use cbd oil with zoloft me face Is my face so worthless If you Cbd Oil Recommended Dosage can you use cbd oil with zoloft say that, then spanking your ass can you use cbd oil with zoloft would be a spanking of me Qin Shaoyou gave Zhu Xiucai a blank look and waved his hand Okay, You don t need to be flattering, let s talk about it, what the hell is going on I didn t flatter, my feelings for adults can you use cbd oil with zoloft Liv Labs Cbd Oil Reviews come from the bottom of my heart.

As soon can you use cbd oil with zoloft as she heard that eating this thing can strengthen her blood and improve her cultivation, she can you use cbd oil with zoloft immediately changed her Cbd Oil For Tremors can you use cbd oil with zoloft mouth Bring it to you At the same time, her hands quickly reached out, making a sneak attack by a black tiger, which was too fast to cover her ears.

The intuition that can make Lord Qianhu talk about it should not be bad, maybe he can really gain insight into the whereabouts of the corpse demon and the corpse king.

After Qin Shaoyou instructed can you use cbd oil with zoloft Lux, he would continue to make work arrangements.

Wanting to obtain the self healing ability of rebirth from severed limbs has become wishful thinking.

The can you use cbd oil with zoloft result of this divination, you can say that it indicates can you use cbd oil with zoloft that the murderer has not yet run can you use cbd oil with zoloft away, and there is a chance to catch him.

And in the Shuangmantian Secret Book that I just got today, there is also a set of Tibetan methods.

The incident happened next to the county school.

Zuo Qianhu rode his horse to meet the eighteen riders who were waiting in the distance.

Fazihe Qin Shaoyou frowned slightly. On the third day of the third lunar month, it was by this river that hundreds of lives can you take a cbd gummies if you smoked weed of the Yaosi of Luocheng Town were buried.

They also made a sound, but it was not the tinkling, tinkling that a bell should have, but a strange, scalp tingling cry.

It was not until gold bee cbd oil canada it was getting late that Qin Shaoyou said goodbye to the sisters of the can you use cbd oil with zoloft Su family who were still unfinished, and prepared to leave the Jade Emperor Temple and return to Luocheng.

Hundred Bombing Zhenjun is cbd oil approved by the fda doesn t explode, Cbd Oil For Tremors can you use cbd oil with zoloft is it still Baizhuang Zhenjun can you use cbd oil with zoloft I have to get some talismans in the future.

Qin Shaoyou also wrote down all of them. Just when Qin Shaoyou was about zero tch cbd oil hawaii to thank Xue Qingshan, Xue Xiaobao pulled the corner of his shirt and made can you use cbd oil with zoloft a request Little uncle, can you take me with you when you go to Mianyuan County You go to Mianyuan.

The crowd attacked. Is this seemingly tattered cassock still a baby Seeing Qin Shaoyou s surprise and curiosity, Xue Qingshan whispered in his ear Master Suquan s robe is not simple.

Now, when you encounter disasters, you are blaming me Are you embarrassed Do you can you use cbd oil with zoloft have this face Let the murderer be the one who is afraid of being robbed of money to report to the officials, so you have to keep your mouth shut.

And when he heard that Qin Shaoyou and others came to find him to go to the Jade Emperor Temple, his face darkened instantly.

Even the eyes were sore and sore, and tears flowed, which made everyone very uncomfortable.

Cui Youkui glanced at the monk with satisfaction, thinking that this person is really a good one.

What happened last night Not only was she confused, but An Qin and An Mutong were equally puzzled.

He went back and apologized to the fifth sister and the fifth brother in law, telling them that he had to work overtime in a sudden case and could not accompany him.

Qin Shaoyou and a few people came to the gate of the Jade Emperor Temple.

I can t believe the technique of observing Qi and seeing cbd gummies get you high shape. can you use cbd oil with zoloft

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